The ratio of T1-Weighted to T2-Weighted Signal Intensity and IDH mutation in glioma
Takahiro Sanada1, Shota Yamamoto1, Hirotaka Sato1,2, Mio Sakai3, Masato Saito1, Nobuyuki Mitsui1, Satoru Hiroshima1, Ryogo Anei4, Yonehiro Kanemura5, Katsuyuki Nakanishi3, Haruhiko Kishima6, and Manabu Kinoshita1
1Neurosurgery, Asahikawa Medical University, Asahikawa, Japan, 2Neurosurgery, Japanese Red Cross Kitami Hospital, Asahikawa, Japan, 3Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka, Japan, 4Neurosurgery, Moriyama Hospital, Asahikawa, Japan, 5Biomedical Research and Innovation, National Hospital Organization Osaka National Hospital, Osaka, Japan, 6Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan
The authors investigated the correlation of the ratio of T1WI to T2WI signal intensity (rT1/T2) and IDH mutation status in lower-grade gliomas (LrGG). An exploratory study was conducted to determine an ideal cut-off of rT1/T2 for predicting IDH-mutation, followed by a validation study using two different cohorts. Mean rT1/T of IDH-wild type LrGG was higher than IDH-mutant and significantly predicted IDH mutation in the exploratory cohort. The domestic cohort validated this result, but the accuracy in the TCIA / TCGA cohort declined. The cause of this decline should be further investigated.
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