Abstract #3061

The ratio of T1-Weighted to T2-Weighted Signal Intensity and IDH mutation in glioma

Takahiro Sanada¹, Shota Yamamoto¹, Hirotaka Sato^1,2, Mio Sakai³, Masato Saito¹, Nobuyuki Mitsui¹, Satoru Hiroshima¹, Ryogo Anei⁴, Yonehiro Kanemura⁵, Katsuyuki Nakanishi³, Haruhiko Kishima⁶, and Manabu Kinoshita¹

¹Neurosurgery, Asahikawa Medical University, Asahikawa, Japan, ²Neurosurgery, Japanese Red Cross Kitami Hospital, Asahikawa, Japan, ³Diagnostic and Interventional Radiology, Osaka International Cancer Institute, Osaka, Japan, ⁴Neurosurgery, Moriyama Hospital, Asahikawa, Japan, ⁵Biomedical Research and Innovation, National Hospital Organization Osaka National Hospital, Osaka, Japan, ⁶Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan

Synopsis

The authors investigated the correlation of the ratio of T1WI to T2WI signal intensity (rT1/T2) and IDH mutation status in lower-grade gliomas (LrGG). An exploratory study was conducted to determine an ideal cut-off of rT1/T2 for predicting IDH-mutation, followed by a validation study using two different cohorts. Mean rT1/T of IDH-wild type LrGG was higher than IDH-mutant and significantly predicted IDH mutation in the exploratory cohort. The domestic cohort validated this result, but the accuracy in the TCIA / TCGA cohort declined. The cause of this decline should be further investigated.

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