Microstructural Deviation in Parkinson’s Disease and Multiple System Atrophy Detected by Spatial Normative Models
Chang-Le Chen1,2, Ming-Che Kuo3, Chun-Hwei Tai3, Yung-Chin Hsu4, Ruey-Meei Wu3, and Wen-Yih Isaac Tseng1,5
1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, 3Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, 4AcroViz Technology Inc., Taipei, Taiwan, 5Molecular Imaging Center, National Taiwan University, Taipei, Taiwan
By applying spatial normative models based on a population-based cohort, we can quantify the microstructural deviation of white matter in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA). We found that microstructural deviation of the frontal aslant tracts, cerebrospinal tracts, and parts of corpus callosum was more profound in MSA compared to that in PD. Also, the uncinate fasciculi were the common degenerative marker in these two diseases. Moreover, the microstructural deviation of WM tracts may reflect the association with the disease-related daily functional deficit in MSA and the timing of disease onset in PD.
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