Abstract #3065

Microstructural Deviation in Parkinson’s Disease and Multiple System Atrophy Detected by Spatial Normative Models

Chang-Le Chen^1,2, Ming-Che Kuo³, Chun-Hwei Tai³, Yung-Chin Hsu⁴, Ruey-Meei Wu³, and Wen-Yih Isaac Tseng^1,5

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ³Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan, ⁴AcroViz Technology Inc., Taipei, Taiwan, ⁵Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

Synopsis

By applying spatial normative models based on a population-based cohort, we can quantify the microstructural deviation of white matter in patients with Parkinson’s disease (PD) and multiple system atrophy (MSA). We found that microstructural deviation of the frontal aslant tracts, cerebrospinal tracts, and parts of corpus callosum was more profound in MSA compared to that in PD. Also, the uncinate fasciculi were the common degenerative marker in these two diseases. Moreover, the microstructural deviation of WM tracts may reflect the association with the disease-related daily functional deficit in MSA and the timing of disease onset in PD.

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