Abstract #3066

Fixel-Based Analysis Identifies White Matter Tract Degeneration in Parkinson’s Disease with Mild Cognitive Impairment

Chih-Chien Tsai^1,2, Ting-Wei Liao³, Yih-Ru Wu^3,4, Yi-Ming Wu⁵, and Jiun-Jie Wang^2,6,7

¹Department of Medical imaging and Radiological Science, Chang Gung University, Taoyuan City, Taiwan, ²Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan, ³Department of Neurology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, ⁴College of Medicine, Chang Gung University, Taoyuan City, Taiwan, ⁵Department of f Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, ⁶Department of Medical imaging and Radiological Science, Chang-Gung University, Taoyuan City, Taiwan, ⁷Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan City, Taiwan

Synopsis

Cognitive decline is a common non-motor symptom in Parkinson's disease (PD) patients, described as mild cognitive impairment (PD-MCI). PD-MCI is identified as a risk for PD with Dementia. Previous studies indicated that PD-MCI patients showed gray matter volume decrease and white matter tract degeneration. We investigate the utility of fixel based analysis as a biomarker for disease progression. The results show a significant degeneration of white matter in PD-MCI patients. Our findings indicated the white matter tract degeneration in PD-MCI patients and shed light on the value of the fiber-specific method to the clinical diagnosis of PD-MCI.

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