Abstract #3066
Fixel-Based Analysis Identifies White Matter Tract Degeneration in Parkinson’s Disease with Mild Cognitive Impairment
Chih-Chien Tsai1,2, Ting-Wei Liao3, Yih-Ru Wu3,4, Yi-Ming Wu5, and Jiun-Jie Wang2,6,7
1Department of Medical imaging and Radiological Science, Chang Gung University, Taoyuan City, Taiwan, 2Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan, 3Department of Neurology, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, 4College of Medicine, Chang Gung University, Taoyuan City, Taiwan, 5Department of f Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan City, Taiwan, 6Department of Medical imaging and Radiological Science, Chang-Gung University, Taoyuan City, Taiwan, 7Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Taoyuan City, Taiwan
Synopsis
Cognitive decline is a common non-motor symptom in Parkinson's disease (PD) patients, described as mild cognitive impairment (PD-MCI). PD-MCI is identified as a risk for PD with Dementia. Previous studies indicated that PD-MCI patients showed gray matter volume decrease and white matter tract degeneration. We investigate the utility of fixel based analysis as a biomarker for disease progression. The results show a significant degeneration of white matter in PD-MCI patients. Our findings indicated the white matter tract degeneration in PD-MCI patients and shed light on the value of the fiber-specific method to the clinical diagnosis of PD-MCI.
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