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Abstract #3068

Quantitative Evaluation of Substantia Nigra Degeneration in Parkinson’s Disease using T1 mapping

Ayaka Yokota1, Yasuhiro Fujiwara2, Tetsuyoshi Hirai3, Nobutaka Sakae4, Naokazu Sasagasako4, Takahisa Izumi5, Kuniharu Ohi5, and Hiroyuki Kumazoe5
1Graduated School of Health Sciences, Kumamoto University, Kumamoto, Japan, 2Department of Medical Image Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 3Faculty of Medicine, Saga University, Saga, Japan, 4Department of Neurology, National Hospital Organization Omuta National Hospital, Omuta, Japan, 5Department of Radiology, National Hospital Organization Omuta National Hospital, Omuta, Japan

Synopsis

We evaluated the T1 values of the whole and subregions of the substantia nigra (SN) in patients with Parkinson's disease (PD) to identify an imaging biomarker for the early diagnosis of PD. T1 values of the SN of patients with PD were significantly shorter than those of healthy controls and tended to be longer in the lateral part for both groups. T1 values may reflect the pathology of the SN and help assess the degeneration of the SN caused by PD.

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