The whole-brain effective connectivity (EC) was estimated to interpret the brain dynamics, time-dependent communicability and propagation of neuronal activity within the brain state in patients with early onset schizophrenia. We observed decreased effective connectivity (p<0.05) and global integration of local endogenous events in early onset schizophrenia (EOS) as compared to controls. EOS suffer decreased propagation of neuronal activity and responsiveness to events.
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