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Abstract #3070

Decreased the stability of brain hubs and the heterogeneity of whole brain dynamics in early onset schizophrenia

Mukesh Kumar1, S Senthil Kumaran1, Pankaj Pankaj1, and Rajesh Sagar2
1Department of NMR & MRI Facility, All India Institute of Medical Sciences, New Delhi, India, 2Department of psychiatry, All India Institute of Medical Sciences, New Delhi, India


The whole-brain effective connectivity (EC) was estimated to interpret the brain dynamics, time-dependent communicability and propagation of neuronal activity within the brain state in patients with early onset schizophrenia. We observed decreased effective connectivity (p<0.05) and global integration of local endogenous events in early onset schizophrenia (EOS) as compared to controls. EOS suffer decreased propagation of neuronal activity and responsiveness to events.

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