Schizophrenia is characterized by abnormal functional integration between distinct brain regions but whether a common deficit in functional connectivity in relation to both clinical symptoms and cognitive impairments would present in drug-naïve first-episode patients remains elusive. A connectome-wise analysis on resting-state functional MRI in never-treated patients with first-episode schizophrenia. Using the principal component analysis, we found a trans-symptomatic pattern of functional connectivity associated with both psychopathological and cognitive manifestations in never-treated first-episode schizophrenia characterized as the dysconnections involving frontal and visual cortices, suggesting a core deficit of brain functional connectivity that might underpin the psychopathology of schizophrenia.
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