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Abstract #3071

Linked brain connectivity patterns with psychopathological and cognitive phenotypes in drug-naïve first-episode schizophrenia

Hui Sun1, Wenjing Zhang1, Chengmin Yang1, Qiyong Gong1, and Su Lui1
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China


Schizophrenia is characterized by abnormal functional integration between distinct brain regions but whether a common deficit in functional connectivity in relation to both clinical symptoms and cognitive impairments would present in drug-naïve first-episode patients remains elusive. A connectome-wise analysis on resting-state functional MRI in never-treated patients with first-episode schizophrenia. Using the principal component analysis, we found a trans-symptomatic pattern of functional connectivity associated with both psychopathological and cognitive manifestations in never-treated first-episode schizophrenia characterized as the dysconnections involving frontal and visual cortices, suggesting a core deficit of brain functional connectivity that might underpin the psychopathology of schizophrenia.

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