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Abstract #3073

White matter fiber-specific alterations in bipolar disorder: a fixel-based analysis

Paola Magioncalda1,2, Chun-Hung Yeh3, Hsiang-Yuan Lin4, Rung-Yu Tseng3, Mario Amore5, and Matteo Martino1,2
1Graduate Institute of Mind, Brain, and Consciousness, Taipei Medical University, Taipei, Taiwan, 2Brain and Consciousness Research Centre, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan, 3Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan, 4Azrieli Adult Neurodevelopmental Centre, Campbell Family Mental Health Research Institute, and Adult Neurodevelopmental and Geriatric Psychiatry Division, Centre for Addiction and Mental Health, Toronto, ON, Canada, 5Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy


The recent unified model of the pathophysiology of bipolar disorder (BD) proposed that micro/macrostructural disturbance in limbic white matter (WM) fibers is important in the pathophysiological mechanism of BD. To gain more insights into this model, preprocessed diffusion MRI data of 67 BD and 125 healthy participants were analyzed using fixel-based analysis. We found a reduction of fiber density and/or cross-section of tracts, including the fornix and cingulum bundle that are core elements of the limbic system. These findings robustly support an association of BD with a specific spatial pattern of WM alterations.

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