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Abstract #3080

Functional Deficits in the Large-scale Circuitry Mediate the Links of Structural Atrophy to Social Anxiety Disorder Outcomes

Xun Zhang1, Song Wang1, and Qiyong Gong1
1Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China


Social anxiety disorder (SAD) is a prevalent and disabling psychiatric disorder, for which the underlying neurobiological mechanisms remain poorly understood. Herein, whole-brain voxel-based morphometry and coupled functional connectivity analyses were conducted to investigate structural and functional alterations, while correlation and mediation analyses were performed to probe the potential roles of structural-functional couplings in SAD diagnosis. As a result, we observed significant subcortical grey matter atrophy and widespread dysconnectivity in cortico-striato-thalamo-cerebellar circuitry in SAD; functional dysconnectivity could partially mediate the effects of structural atrophy on SAD diagnosis, which may contribute to clarifying the underlying mechanisms of structure-functional couplings for SAD.

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