Aberrant Intrinsic Functional Connectivity of Hippo-Orbitofrontal-Insular Circuit in Drug-naive Adolescents with Major Depressive Disorder
Zilin Zhou1, Yingxue Gao1, Weijie Bao1, Hui Qiu1, Lianqing Zhang1, Ruohan Feng1,2, Yingying Wang1, Mengyue Tang1, Qiyong Gong1, and Xiaoqi Huang1
1Department of Radiology, Huaxi Magnetic Resonance Research Centre (HMRRC),Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu, China, 2Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China
Through seed-based functional connectivity (SBFC) analysis, we investigated the altered intrinsic connectivity patterns of hippocampus, orbitofrontal cortex (OFC) and insula in adolescents with major depressive disorder(aMDD) comparing to typically developing control(TDC). We found distinct network alterations of those three structures at regional and subregional level. Moreover, we located the aberrant connectivity in hippo-orbitofrontal-insular circuit with family conflict and depressvie symptoms in aMDD which may underline the neural mechanism for depressvie symptoms in adolescents.
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