Abstract #3079

Aberrant Intrinsic Functional Connectivity of Hippo-Orbitofrontal-Insular Circuit in Drug-naive Adolescents with Major Depressive Disorder

Zilin Zhou¹, Yingxue Gao¹, Weijie Bao¹, Hui Qiu¹, Lianqing Zhang¹, Ruohan Feng^1,2, Yingying Wang¹, Mengyue Tang¹, Qiyong Gong¹, and Xiaoqi Huang¹

¹Department of Radiology, Huaxi Magnetic Resonance Research Centre (HMRRC),Functional and Molecular Imaging Key Laboratory of Sichuan Province, Chengdu, China, ²Department of Radiology, the Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang, China

Synopsis

Through seed-based functional connectivity (SBFC) analysis, we investigated the altered intrinsic connectivity patterns of hippocampus, orbitofrontal cortex (OFC) and insula in adolescents with major depressive disorder(aMDD) comparing to typically developing control(TDC). We found distinct network alterations of those three structures at regional and subregional level. Moreover, we located the aberrant connectivity in hippo-orbitofrontal-insular circuit with family conflict and depressvie symptoms in aMDD which may underline the neural mechanism for depressvie symptoms in adolescents.

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