Through seed-based functional connectivity (SBFC) analysis, we investigated the altered intrinsic connectivity patterns of hippocampus, orbitofrontal cortex (OFC) and insula in adolescents with major depressive disorder(aMDD) comparing to typically developing control(TDC). We found distinct network alterations of those three structures at regional and subregional level. Moreover, we located the aberrant connectivity in hippo-orbitofrontal-insular circuit with family conflict and depressvie symptoms in aMDD which may underline the neural mechanism for depressvie symptoms in adolescents.
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