Present study investigated volumetric changes in the brain of Indian patients suffering from Major Depressive Disorder (MDD) using Magnetic Resonance Imaging (MRI). These patients were seen to have significantly reduced brain and cerebellar volumes. Volume of caudate, putamen and globus pallidus were seen to be reduced but no significant changes were seen in hippocampus and amygdala. Volume of cerebellum and lobule VI of cerebellum was also reduced. Our results suggest that cerebellum as well as VI lobule of cerebellum may be associated with MDD.