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Abstract #3077

Changes in neurochemicals of patients with depression observed using two MRS sequences at 7T

Tomohisa Okada1, Yujiro Yoshihara2, Manabu Kubota2, Taro Suwa2, Jun Miyata2, Yuhei Takado3, Jamie Near4, Masoumeh Dehghani4, Thai Akasaka1, Dinh Ha Duy Thuy1, Ravi Teja Seethamraju5, Sinyeob Ahn6, Tadashi Isa1, and Toshiya Murai2
1Human Brain Research Center, Kyoto University, Kyoto, Japan, 2Department of Psychiatry, Kyoto University, Kyoto, Japan, 3Department of Functional Brain imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, 4Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, 5Siemens Healthcare USA, Boston, MA, United States, 6Siemens Healthcare USA, Berkeley, CA, United States


Major depressive disorder (MDD) afflicts up to 20% of the total population. MRS findings are different among studies. One of the reasons is differences in MRS sequences used. This study compared two sequences: sSPECIAL and STEAM, which consistently found significant and marginally significant reduction of taurine in the anterior cingulate cortex in MDD compared with healthy controls, although concentration of neurochemicals in sSPECIAL and STEAM was different. The difference was lost when concentration was normalized by total creatine due to its significant positive correlation to Taurine. Differences between the two sequences did not result in different neurochemical findings for MDD.

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