Abstract #3077

Changes in neurochemicals of patients with depression observed using two MRS sequences at 7T

Tomohisa Okada¹, Yujiro Yoshihara², Manabu Kubota², Taro Suwa², Jun Miyata², Yuhei Takado³, Jamie Near⁴, Masoumeh Dehghani⁴, Thai Akasaka¹, Dinh Ha Duy Thuy¹, Ravi Teja Seethamraju⁵, Sinyeob Ahn⁶, Tadashi Isa¹, and Toshiya Murai²

¹Human Brain Research Center, Kyoto University, Kyoto, Japan, ²Department of Psychiatry, Kyoto University, Kyoto, Japan, ³Department of Functional Brain imaging, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ⁴Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ⁵Siemens Healthcare USA, Boston, MA, United States, ⁶Siemens Healthcare USA, Berkeley, CA, United States

Synopsis

Major depressive disorder (MDD) afflicts up to 20% of the total population. MRS findings are different among studies. One of the reasons is differences in MRS sequences used. This study compared two sequences: sSPECIAL and STEAM, which consistently found significant and marginally significant reduction of taurine in the anterior cingulate cortex in MDD compared with healthy controls, although concentration of neurochemicals in sSPECIAL and STEAM was different. The difference was lost when concentration was normalized by total creatine due to its significant positive correlation to Taurine. Differences between the two sequences did not result in different neurochemical findings for MDD.

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