Using seed based FC analysis, we investigated alterations in functional connectivity of amygdala subregional networks in a relatively large sample of adolescent MDD. Our findings identified adolescent MDD patients, compared to HC, have anomalous amygdala subregional functional network connections to several brain regions that play a pivotal role in emotional and cognitive processing, which may contribute to revealing the pathophysiology underlying MDD. These findings were not detected when using the whole amygdala as seeds, further verify the significance of analyses at the subregion level.
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