Abstract #3075

Disrupted white matter network of brain structural connectomes in bipolar disorder patients revealed by q-ball imaging

Pei-Ti Lin¹, Huai-Hsuan Tseng^2,3, Po See Chen^2,3, and Jun-Cheng Weng^1,4,5

¹Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, ²Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ³Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁴Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ⁵Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan

Synopsis

Bipolar disorder (BD) is a major psychiatric disorder associated with structural and functional brain alterations and cognitive deficits. This study used q-ball imaging and graph theoretical analysis to investigate both neurological structural change and network alterations between BD patients and healthy controls. The results showed the alterations in several brain regions including the corpus callosum and cingulate gyrus, which are associated with executive, cognitive, emotional function, and memory. We found the BD group demonstrated higher global integrity than the HC group, but they remained small-world properties. It indicated that white matter integrity and network alterations were associated with bipolar disorder.

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