Disrupted white matter network of brain structural connectomes in bipolar disorder patients revealed by q-ball imaging
Pei-Ti Lin1, Huai-Hsuan Tseng2,3, Po See Chen2,3, and Jun-Cheng Weng1,4,5
1Department of Medical Imaging and Radiological Sciences, Graduate Institute of Artificial Intelligence, Chang Gung University, Taoyuan, Taiwan, 2Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 3Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 4Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, 5Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan
Bipolar disorder (BD) is a major psychiatric disorder associated with structural and functional brain alterations and cognitive deficits. This study used q-ball imaging and graph theoretical analysis to investigate both neurological structural change and network alterations between BD patients and healthy controls. The results showed the alterations in several brain regions including the corpus callosum and cingulate gyrus, which are associated with executive, cognitive, emotional function, and memory. We found the BD group demonstrated higher global integrity than the HC group, but they remained small-world properties. It indicated that white matter integrity and network alterations were associated with bipolar disorder.
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