Fast and accurate creatine chemical exchange saturation transfer muscle imaging with quasi-steady state post-processing algorithm at 3T
Zhou Liu1,2, Qian Yang1, Honghong Luo1, Dehong Luo1, Long Qian3, Xin Liu2, Hairong Zheng2, Phillip Zhe Sun4, and Yin Wu2
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, 2Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 3GE Healthcare, Beijing, China, 4Emory University School of Medicine, Atlanta, GA, United States
Although CrCEST MRI is increasingly employed in muscle imaging, its measurement depends on the RF saturation duration (Ts) and relaxation delay (Td). This study evaluated the quasi-steady-state (QUASS) algorithm for fast and robust CrCEST measurement. Briefly, CrCEST experiments were performed at 3T under two representative imaging conditions. Both phantom and volunteer experiments showed that the routine CrCEST increased significantly with Ts and Td and were significantly smaller than the corresponding QUASS indices. In comparison, the QUASS CrCEST meaurement showed little dependence on the scan protocol, establishing the robustness and accuracy of QUASS CrCEST muscle MRI.
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