Abstract #3106

Fast and accurate creatine chemical exchange saturation transfer muscle imaging with quasi-steady state post-processing algorithm at 3T

Zhou Liu^1,2, Qian Yang¹, Honghong Luo¹, Dehong Luo¹, Long Qian³, Xin Liu², Hairong Zheng², Phillip Zhe Sun⁴, and Yin Wu²

¹National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, ²Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ³GE Healthcare, Beijing, China, ⁴Emory University School of Medicine, Atlanta, GA, United States

Synopsis

Although CrCEST MRI is increasingly employed in muscle imaging, its measurement depends on the RF saturation duration (Ts) and relaxation delay (Td). This study evaluated the quasi-steady-state (QUASS) algorithm for fast and robust CrCEST measurement. Briefly, CrCEST experiments were performed at 3T under two representative imaging conditions. Both phantom and volunteer experiments showed that the routine CrCEST increased significantly with Ts and Td and were significantly smaller than the corresponding QUASS indices. In comparison, the QUASS CrCEST meaurement showed little dependence on the scan protocol, establishing the robustness and accuracy of QUASS CrCEST muscle MRI.

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