Iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ) is a chemical shift encoding-based water-fat MRI technique which allows noninvasive fat quantification. In this study, we investigated the correlation between thigh muscle fat fraction (FF) and isokinetic strength measurements in middle-aged and elderly obese participants with T2DM scanned at 3.0T MR. Intramuscular FF was shown to be a significant predictor of peak torque (PT) and total work (TW) in the thigh muscle. Therefore, intramuscular FF might provide reliable imaging markers for the prevention and monitoring of thigh muscle dysfunction in participants with T2DM.
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