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Abstract #3107

Association of Thigh Muscle Fat with Isometric Strength Measurements in Patients with T2DM  Using Chemical Shift Encoding-Based Water-Fat MRI

Hongli Zhu1, Yilong Huang1, Lisha Nie2, Hanxue Cun1, Tianfu Qi1, and Bo He1
1Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, China, 2GE Healthcare, MR Research China, Beijing, China


Iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation sequence (IDEAL-IQ) is a chemical shift encoding-based water-fat MRI technique which allows noninvasive fat quantification. In this study, we investigated the correlation between thigh muscle fat fraction (FF) and isokinetic strength measurements in middle-aged and elderly obese participants with T2DM scanned at 3.0T MR. Intramuscular FF was shown to be a significant predictor of peak torque (PT) and total work (TW) in the thigh muscle. Therefore, intramuscular FF might provide reliable imaging markers for the prevention and monitoring of thigh muscle dysfunction in participants with T2DM.

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