Muscle hyperemia after exercise is a physiologic phenomenon that could reflect muscle function and performance. For a group of human subjects, we performed dynamic BOLD scan of calf muscles immediately after in-scanner plantar flexion. To analyze the dynamic data, a kinetic model of deoxy-hemoglobin (dHb) was proposed, with exponentially decayed perfusion as determinant. A hyperemia index (HI) was defined based on the estimated perfusion parameters, and was compared to muscle perfusion measured by DCE scans. In conclusion, we proposed a quantitative model for analyzing post-exercise muscle BOLD data, and the new parameter “hyperemia index”.
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