Abstract #3108

Exercise-induced muscle hyperemia as quantified by a BOLD modelling approach

Yujie Wang^1,2, Christopher J. Hanrahan³, and Jeff L. Zhang¹

¹Vascular and Physiologic Imaging Research (VPIR) Lab, School of Biomedical Engineering, ShanghaiTech University, Shanghai, China, ²School of Life Science and Technology, ShanghaiTech University, Shanghai, China, ³Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

Synopsis

Muscle hyperemia after exercise is a physiologic phenomenon that could reflect muscle function and performance. For a group of human subjects, we performed dynamic BOLD scan of calf muscles immediately after in-scanner plantar flexion. To analyze the dynamic data, a kinetic model of deoxy-hemoglobin (dHb) was proposed, with exponentially decayed perfusion as determinant. A hyperemia index (HI) was defined based on the estimated perfusion parameters, and was compared to muscle perfusion measured by DCE scans. In conclusion, we proposed a quantitative model for analyzing post-exercise muscle BOLD data, and the new parameter “hyperemia index”.

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