Fat content in lower limb is of highly clinical interest as it reflects physical activity. In this study, we quantified lower-limb fat content in a comprehensive way using a Dixon method. We found that fat content in lower limb generally decreased from pelvis to ankle. Of particular note, fat content in thigh was significantly higher than that in calf, and can potentially differentiate subjects with different body-mass index (BMI). It is also encouraging that fat content for a single cross-section at mid-thigh (30 sec scan time) approximated whole-limb fat content well, as it makes whole-body quantification in clinical setting feasible.
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