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Abstract #3122

Fibre-specific white matter alterations in recovered COVID-19 patients

Yu Shen1, Yan Bai1, Xianchang Zhang2, Yaping Wu1, Menghuan Zhang1, and Meiyun Wang1
1Henan Provincial People's Hospital, Zhengzhou, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China


The brain fibre-specific changes in patients who recovered from Coronavirus Disease 2019 (COVID-19) for one year but still had anosmia (reCOVID19_ano) deserves to be investigated. This study used fixel based analysis (FBA), which is a novel diffusion MRI post-processing technique that enables fibre tract-specific statistical analysis, to investigate the white matter alterations in reCOVID19_ano. The results revealed that the intra-axonal volume in reCOVID19_ano was significantly increased in several fibre tracts. We speculate that impaired fibre tracts may recover gradually in a compensatory mechanism after one year recovery in reCOVID19_ano patients.

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