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Abstract #3122

Fibre-specific white matter alterations in recovered COVID-19 patients

Yu Shen1, Yan Bai1, Xianchang Zhang2, Yaping Wu1, Menghuan Zhang1, and Meiyun Wang1
1Henan Provincial People's Hospital, Zhengzhou, China, 2MR Collaboration, Siemens Healthineers Ltd, Beijing, China

Synopsis

The brain fibre-specific changes in patients who recovered from Coronavirus Disease 2019 (COVID-19) for one year but still had anosmia (reCOVID19_ano) deserves to be investigated. This study used fixel based analysis (FBA), which is a novel diffusion MRI post-processing technique that enables fibre tract-specific statistical analysis, to investigate the white matter alterations in reCOVID19_ano. The results revealed that the intra-axonal volume in reCOVID19_ano was significantly increased in several fibre tracts. We speculate that impaired fibre tracts may recover gradually in a compensatory mechanism after one year recovery in reCOVID19_ano patients.

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