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Abstract #3130

Combined 7T CEST/MRS imaging to predict tumor metabolism in glioma

Yifan Yuan1, Qi Yue1, Xiang Zou1, Yu Guo1, Ying-Hua Chu2, Yi-Cheng Hsu2, Patrick Liebig3, Wenwen Yu4, He Wang4,5, Liang Chen1, and Ying Mao1
1Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China, 2Siemens Healthineers Ltd., Shanghai, China, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 5Human Phenome Institute, Fudan University, Shanghai, China


Magnetic resonance imaging has been applied in intraoperative neuro-navigation and irradiation guidance in glioma diagnosis. The contrast-enhanced MRI or peritumor edema on T2w image is not precise enough to delineate tumor infiltration. MR spectroscopy (MRS) and chemical exchange saturation transfer (CEST) have been used to evaluate tumor metabolism. Studies showed that amino acid PET surpassed conventional MR imaging for tumor delineation. Here, we explored the correlation between MRS and CEST at 7T and chose PET as gold standard to investigate multimodal MR imaging for glioma metabolic characteristics and tumor extent. An exemplary case with stereotactic biopsy proof was shown.

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