Magnetic resonance imaging has been applied in intraoperative neuro-navigation and irradiation guidance in glioma diagnosis. The contrast-enhanced MRI or peritumor edema on T2w image is not precise enough to delineate tumor infiltration. MR spectroscopy (MRS) and chemical exchange saturation transfer (CEST) have been used to evaluate tumor metabolism. Studies showed that amino acid PET surpassed conventional MR imaging for tumor delineation. Here, we explored the correlation between MRS and CEST at 7T and chose PET as gold standard to investigate multimodal MR imaging for glioma metabolic characteristics and tumor extent. An exemplary case with stereotactic biopsy proof was shown.
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