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Abstract #3137

Differentiation of T1 stage nasopharyngeal carcinoma and lymphoid hyperplasia by mono-exponential and bi-exponential metrics of TSE DWI

Yifan Liu1, Shasha Bao1, Nan Xu1, Xiaobin Guo1, Chengde Liao1, Zhongping Zhang2, and Tengfei Ke1
1Dept. of Radiology, Yunnan Cancer Hospital, Kunming, China, 2Philips Healthcare China, Guangzhou, China


We aimed to differentiate between T1 stage nasopharyngeal carcinoma (NPC) and nasopharyngeal lymphoid hyperplasia using multiple b-values Turbo-spin-echo DWI acquisition. Turbo-spin-echo DWI were adopted to minimize susceptibility artifacts in nasopharynx. Mono-exponential and bi-exponential models were both used to generate ADC, D, D* and f maps. We found that T1 stage NPC had significant lower ADC and D, higher D* than nasopharyngeal lymphoid hyperplasia. Furthermore, D has best diagnostic efficacy with highest area under curve in ROC analysis, indicating that it's a potential imaging biomarker for accurate early diagnosis of T1 stage NPC.

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