Dysfunction of energy supply or usage may be present in Multiple Sclerosis. We investigated the use of a simple oxygen diffusion model to infer mitochondrial oxygen tension from dual-calibrated fMRI (dc-fMRI) data. We observed a significant reduction of grey matter CBF and CMRO2 in people with MS but no significant difference in OEF or BOLD-sensitive blood volume. Assuming no substantial tissue or vascular remodelling in MS, these results imply, within a simple flow-diffusion model of oxygen from capillaries into the tissue, an elevated partial pressure of oxygen at the mitochondria which may indicate mitochondrial dysfunction.
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