Evidence from dual-calibrated fMRI for raised mitochondrial oxygen tension in the MS brain
Antonio Maria Chiarelli1, Eleonora Patitucci2, Hannah Chandler2, Valentina Tomassini1,3,4,5, Michael Germuska2,6, and Richard Wise1,2
1Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti Pescara, Chieti Scalo, Italy, 2CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Helen Durham Centre for Neuroinflammation, University Hospital of Wales, Cardiff, United Kingdom, 4MS Centre, Neurology Unit, “SS. Annunziata” University Hospital, Chieti, Italy, 5Division of Psychological Medicine and Clinical Neurosciences, University Hospital of Wales, Cardiff, United Kingdom, 6School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom
Dysfunction of energy supply or usage may be present in Multiple Sclerosis. We investigated the use of a simple oxygen diffusion model to infer mitochondrial oxygen tension from dual-calibrated fMRI (dc-fMRI) data. We observed a significant reduction of grey matter CBF and CMRO2 in people with MS but no significant difference in OEF or BOLD-sensitive blood volume. Assuming no substantial tissue or vascular remodelling in MS, these results imply, within a simple flow-diffusion model of oxygen from capillaries into the tissue, an elevated partial pressure of oxygen at the mitochondria which may indicate mitochondrial dysfunction.
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