Abstract #3253

Association of Blood Biomarkers and Brain Tissue Volume Loss in Patients of Mild Cognitive Impairment and Alzheimer’s Disease

Geon-Ho Jahng¹, Kyung Mi Lee², Sang Tae Kim³, Soonchan Park¹, Sue Min Jung⁴, Hak Young Rhee⁵, Chang-Woo Ryu¹, and Eui Jong Kim²

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Radiology, Kyung Hee University Hospital, Seoul, Korea, Republic of, ³Surgery & Neurology, Bundang Hospital, Seongnam city, Korea, Republic of, ⁴Biomedical Engineering, Kyung Hee University, Yongin-si, Korea, Republic of, ⁵Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

Synopsis

To report the values of a battery of blood inflammatory biomarkers from cognitive normal (CN) to Alzheimer’s disease (AD) in our reasonably sized patient cohort and to evaluate the association between gray matter volume (GMV) loss in AD and plasma levels of blood biomarkers, we included 38 elderly CN elderly, 40 mild cognitive impairment (MCI), and 33 AD subjects and obtained blood biomarkers and GMV. We found that GMV was negatively associated with the levels of IL1b, P-tau, and T-tau. There were no significant associations between brain tissue volumes and the levels of mAβ, NLRP3, miR155, oAβ, and Nogo-A.

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