Subjective cognitive decline (SCD) is a risk factor for dementia. However, multiple pathologies, including amyloid deposition, cerebrovascular pathology, and depression, contribute to the heterogeneity in SCD. We included 170 non-demented elderly with 2-years follow-up to examine brain structural abnormalities in SCD. We found progressive and stable SCD individuals differed in deep white matter hyperintensities and temporoparietal grey matter atrophy. We used multi-model brain and behavioural factors to predict cognitive impairment and dementia progression. Periventricular white matter hyperintensities mediated the effect of amyloid accumulation on cognitive decline and disease severity, while depressive symptoms directly predicted disease severity.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords