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Abstract #3257

Brain structure, amyloid and behavioural features for predicting clinical progression in subjective cognitive decline

Siwei Liu1, Xiao Luo2, Yeerfan Jiaerken2, Joanna Su Xian Chong1, Hee Youn Shim1, Minming Zhang2, and Juan Helen Zhou1
1National University of Singapore, Singapore, Singapore, 2Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China


Subjective cognitive decline (SCD) is a risk factor for dementia. However, multiple pathologies, including amyloid deposition, cerebrovascular pathology, and depression, contribute to the heterogeneity in SCD. We included 170 non-demented elderly with 2-years follow-up to examine brain structural abnormalities in SCD. We found progressive and stable SCD individuals differed in deep white matter hyperintensities and temporoparietal grey matter atrophy. We used multi-model brain and behavioural factors to predict cognitive impairment and dementia progression. Periventricular white matter hyperintensities mediated the effect of amyloid accumulation on cognitive decline and disease severity, while depressive symptoms directly predicted disease severity.

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