Observing Clearance Pathway in Alzheimer Patients Using T2 Component Analysis
Koichi Oshio1, Masao Yui2, Seiko Shimizu2, Shinya Yamada3,4, Madoka Nakajima4, Chihiro Akiba5, Hideki Bandai5, and Masakazu Miyajima6
1Department of Radiology, Juntendo University, Tokyo, Japan, 2Canon Medical Systems Corporation, Otawara, Japan, 3Neurosurgery, Kugayama Hospital, Tokyo, Japan, 4Department of Neurosurgery, Juntendo University, Tokyo, Japan, 5Department of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan, 6Department of Neurosurgery, Junterndo Tokyo Koto Geriatric Medical Center, Tokyo, Japan
A method to visualize possible waste clearance pathway in the brain was proposed earlier. The method is based on an assumption that there exist water containing macromolecules along the clearance pathway, and this water can be visualized using T2 component analysis. Preliminary results of this method applied for Alzheimer patients, as well as healthy volunteers, are presented. Distinct differences between the patients and healthy volunteers were observed. It is expected that this method can be a powerful tool for understanding the patho-physiology of the Alzheimer disease.
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