Abstract #3258

Observing Clearance Pathway in Alzheimer Patients Using T2 Component Analysis

Koichi Oshio¹, Masao Yui², Seiko Shimizu², Shinya Yamada^3,4, Madoka Nakajima⁴, Chihiro Akiba⁵, Hideki Bandai⁵, and Masakazu Miyajima⁶

¹Department of Radiology, Juntendo University, Tokyo, Japan, ²Canon Medical Systems Corporation, Otawara, Japan, ³Neurosurgery, Kugayama Hospital, Tokyo, Japan, ⁴Department of Neurosurgery, Juntendo University, Tokyo, Japan, ⁵Department of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan, ⁶Department of Neurosurgery, Junterndo Tokyo Koto Geriatric Medical Center, Tokyo, Japan

Synopsis

A method to visualize possible waste clearance pathway in the brain was proposed earlier. The method is based on an assumption that there exist water containing macromolecules along the clearance pathway, and this water can be visualized using T2 component analysis. Preliminary results of this method applied for Alzheimer patients, as well as healthy volunteers, are presented. Distinct differences between the patients and healthy volunteers were observed. It is expected that this method can be a powerful tool for understanding the patho-physiology of the Alzheimer disease.

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