Hippocampal subfield-specific alterations in post-stroke dementia with subcortical lesion
Yihan Wu1,2, Huaying Cai3, Linhui Ni3, Guocan Han4, Zhiyong Zhao1, and Dan Wu1
1Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, Hangzhou, China, 2College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China, Hangzhou, China, 3Department of Neurology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China,, Hangzhou, China, 4Department of Radiology, Neuroscience Center, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China, Hangzhou, China
The present study aimed to explore functional and structural alterations in hippocampus and its subfields in post-stroke dementia (PSD). We collected resting-state fMRI and DTI data from 24 PSD patients, 36 post-stroke nondemented (PSND) patients and 21 normal controls (NC). Comparisons between groups found that PSD patients showed subfield-specific changes in the microstructures of hippocampus compared with the other two groups. Moreover, we not only found more PSD-related changes of functional connectivity with cortical regions in the subfields than entire hippocampus, but also revealed the different contributions of subfields on the connectivity changes of entire hippocampus.
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