Improved Multiple Sclerosis Lesion Visualization using Tailored FLAWS-MP2RAGE at 7T
Zhe Zhang1,2, Chenyang Gao3, Wanlin Zhu1,2, Yingkui Zhang1,2, Qingle Kong4, Decai Tian3, Jing Jing1,2, and Yongjun Wang1,2,3
1Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 2China National Clinical Research Center for Neurological Diseases, Beijing, China, 3Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4MR Collaboration, Siemens Healthineers Ltd., Beijing, China
Accurate visualization and evaluation of the MS lesions is an essential step for clinical practice. FLAWS-MP2RAGE has been proposed and applied at ultra-high field to better visualize both white matter and gray matter lesions. This work proposed the optimized method, tailored FLAWS(tFLAWS)-MP2RAGE, using a new image combination method for better lesion contrast. Results of MS patients showed higher lesion CNR of tFLAWS-MP2RAGE compared with conventional FLAWS-MP2RAGE and MPRAGE methods. This method might be a potential tool for lesion detection and evaluation at UHF for MS and other brain diseases.
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