Abstract #3260

Improved Multiple Sclerosis Lesion Visualization using Tailored FLAWS-MP2RAGE at 7T

Zhe Zhang^1,2, Chenyang Gao³, Wanlin Zhu^1,2, Yingkui Zhang^1,2, Qingle Kong⁴, Decai Tian³, Jing Jing^1,2, and Yongjun Wang^1,2,3

¹Tiantan Neuroimaging Center of Excellence, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ²China National Clinical Research Center for Neurological Diseases, Beijing, China, ³Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ⁴MR Collaboration, Siemens Healthineers Ltd., Beijing, China

Synopsis

Accurate visualization and evaluation of the MS lesions is an essential step for clinical practice. FLAWS-MP2RAGE has been proposed and applied at ultra-high field to better visualize both white matter and gray matter lesions. This work proposed the optimized method, tailored FLAWS(tFLAWS)-MP2RAGE, using a new image combination method for better lesion contrast. Results of MS patients showed higher lesion CNR of tFLAWS-MP2RAGE compared with conventional FLAWS-MP2RAGE and MPRAGE methods. This method might be a potential tool for lesion detection and evaluation at UHF for MS and other brain diseases.

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