Abstract #3261

The Contribution of Increased Choroid Plexus Volume in the Alzheimer’s Disease

Jiaxin Li¹, Yueqin Hu², Xue Feng ³, Weiying Dai⁴, Craig H. Meyer³, David C. Alsop⁵, and Li Zhao¹

¹College of Biomedical Engineering & Instrument, Zhejiang University, Hangzhou, China, ²Psychology, Beijing Normal University, Beijing, China, ³Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, ⁴Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ⁵Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Synopsis

Alzheimer’s disease (AD) may be caused by the dysfunction of glymphatic system, in which anatomic changes of the choroid plexus may be associated with reduced CSF production. Our previous work showed significantly increased choroid plexus volume in AD patients compared to healthy controls. However, contributions of the lateral ventricle volume were not investigated. Here, the lateral ventricle and choroid plexus were segmented using two cascaded deep learning models and the volumes were measured on 733 subjects. Increased lateral ventricle volume was found in AD patients, similar to previous studies. More importantly, choroid plexus volume showed a unique contribution to AD.

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