Alzheimer’s disease (AD) may be caused by the dysfunction of glymphatic system, in which anatomic changes of the choroid plexus may be associated with reduced CSF production. Our previous work showed significantly increased choroid plexus volume in AD patients compared to healthy controls. However, contributions of the lateral ventricle volume were not investigated. Here, the lateral ventricle and choroid plexus were segmented using two cascaded deep learning models and the volumes were measured on 733 subjects. Increased lateral ventricle volume was found in AD patients, similar to previous studies. More importantly, choroid plexus volume showed a unique contribution to AD.
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