Coupled Metabolic and Functional Changes in Default Mode Network Subsystems of Alzheimer's Disease: A Hybrid 3D 1H-MRSI/FDG-PET/fMRI Study
Wenli Li1, Miao Zhang2, Rong Guo3,4, Yudu Li3,4, Yibo Zhao3,4, Jialin Hu1, Yaoyu Zhang1, Zhi-Pei Liang3,4, and Yao Li1
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States
The default mode network (DMN) is the first large-scale system disrupted in Alzheimer’s disease (AD). However, the functional and metabolic changes in the DMN subsystems of AD patients are not yet fully understood. This study investigated the coupled functional and metabolic changes of the DMN subsystems by combining high-resolution 3D MRSI, resting-state fMRI, and 18F-FDG PET on a hybrid PET/MR scanner. Our results showed that the DMN subsystems have distinct functional and metabolic associations and contributions to cognitive decline in AD patients. Our findings may provide useful insights into the system-level pathophysiology of AD.
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