The default mode network (DMN) is the first large-scale system disrupted in Alzheimer’s disease (AD). However, the functional and metabolic changes in the DMN subsystems of AD patients are not yet fully understood. This study investigated the coupled functional and metabolic changes of the DMN subsystems by combining high-resolution 3D MRSI, resting-state fMRI, and 18F-FDG PET on a hybrid PET/MR scanner. Our results showed that the DMN subsystems have distinct functional and metabolic associations and contributions to cognitive decline in AD patients. Our findings may provide useful insights into the system-level pathophysiology of AD.
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