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Abstract #3266

Correlation between MRI texture analysis and histo-pathology of Alzheimer’s disease: evaluation in the hippocampus of the Tgf344-AD rat model.

Emma Muñoz-Moreno1, Raul Tudela2,3, Xavier López-Gil1, and Guadalupe Soria4,5
1Magnetic Resonance Imaging Core Facility, IDIBAPS, Barcelona, Spain, 2CIBER-BBN, Barcelona, Spain, 3Universitat de Barcelona, Barcelona, Spain, 4Laboratory of Surgical Neuroanatomy, Universitat de Barcelona, Barcelona, Spain, 5Institute of Neurosciences, Universitat de Barcelona, Barcelona, Spain


β-amyloid plaques and neuroinflammation, two of the pathological processes associated to Alzehimer's disease (AD) are not visible by conventional MRI. However, its presence may induce image changes that can be evaluated using texture analysis. We evaluated the potential of texture analysis of conventional MRI to characterize these changes. T2-weighted MRI of a transgenic rat model of AD were acquired and texture measures in hippocampus were correlated with inmunohistochemical quantification of plaques and microglia, showing significant correlation. Coherently, significant differences in the texture measures were found between transgenic and control animals, pointing to the potential of texture analysis as AD biomarker.

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