Abstract #3267

Measuring changes in placental morphology using magnetic resonance imaging in a preclinical model of human pregnancy

Dimitra Flouri^1,2, Jack RT Darby³, Stacey L Holman³, Sunthara R Perumal⁴, Sebastien Ourselin¹, Anna L David^5,6, Andrew Melbourne^1,2, and Janna L Morrison³

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ³Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, ⁴Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, ⁵Institute for Women's Health, University College London, London, United Kingdom, ⁶NIHR Biomedical Research Center, University College London Hospitals, London, United Kingdom

Synopsis

Abnormalities of placental development and function underlie many pathologies of pregnancy including preeclampsia and fetal growth restriction (FGR). Advances in MRI techniques provide capacity to obtain additional placental in vivo information to support clinical decision-making. Animal models are used in invasive validation studies are possible in animal models and allow for controlled experiments during pregnancy. Here, we investigated whether MRI technology could be used to study the anatomical morphology of placentae in vivo in sheep; and we characterise diffusion and perfusion properties in normal pregnancies and those complicated by induced FGR.

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