Abstract #3268

MRI assessment of placental oxygenation changes in response to maternal hyperoxygenation in a sheep model of human pregnancy

Dimitra Flouri^1,2, Jack RT Darby³, Stacey L Holman³, Georgia K Williams⁴, Sebastien Ourselin¹, Anna L David^5,6, Janna L Morrison³, and Andrew Melbourne^1,2

¹School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, ²Department of Medical Physics & Biomedical Engineering, University College London, London, United Kingdom, ³Early Origins of Adult Health Research Group, University of South Australia, Adelaide, Australia, ⁴Preclinical Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Adelaide, Australia, ⁵Institute for Women's Health, University College London, London, United Kingdom, ⁶NIHR Biomedical Research Center, University College London Hospitals, London, United Kingdom

Synopsis

Abnormalities of placenta development and function may result in fetal growth restriction (FGR). Advances in MRI technology enable estimation of quantitative indices that reflect tissue diffusivity and oxygenation. We investigated the physiological impact of maternal hyperoxygenation on the placenta pregnant sheep. We applied a multi-compartment MRI signal model to measure the changes in oxygenation caused by changes in maternal blood oxygen level. The expected increase in feto-placental blood relaxation and feto-placental oxygen saturation with maternal hyperoxygenation was observed. Results suggested that diffusion and relaxation-based MRI is sensitive to acute changes in maternal and feto-placental oxygen level.

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