Abstract #3272

Longitudinal biochemical and behavioral alterations in a gyrencephalic model of blast related mild traumatic brain injury

Shiyu Tang^1,2, Su Xu^1,2, Li Jiang^1,2, Donna Wilder³, Joseph Long³, Alexandre E. Medina⁴, Xin Li^1,2, Gary Fiskum^5,6, Venkata Siva Sai Sujith Sajja³, and Rao P. Gullapalli^1,2

¹Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Center for Advanced Imaging Research (CAIR), University of Maryland School of Medicine, Baltimore, MD, United States, ³Blast Induced Neurotrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States, ⁴Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States, ⁵Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, United States, ⁶Shock, Trauma, and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Compared to rodents, the ferret model has greater similarities to humans in terms of developmental process, brain structure and sophisticated behavior. In this study, we assessed the longitudinal changes in brain metabolism and impulsivity behavior in a ferret model that closely mimics the blast exposure conditions encountered by Warfighters. Ferrets demonstrated concomitantly increased behavioral impulsivity and metabolite alterations in prefrontal cortex following blast exposure. Our findings agree with clinical observations in patients, suggesting that this model is a good gyrencephalic animal model to study brain biochemical profile changes and neuropsychiatric alterations associated with blast exposure.

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