Abstract #3272
Longitudinal biochemical and behavioral alterations in a gyrencephalic model of blast related mild traumatic brain injury
Shiyu Tang1,2, Su Xu1,2, Li Jiang1,2, Donna Wilder3, Joseph Long3, Alexandre E. Medina4, Xin Li1,2, Gary Fiskum5,6, Venkata Siva Sai Sujith Sajja3, and Rao P. Gullapalli1,2
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Center for Advanced Imaging Research (CAIR), University of Maryland School of Medicine, Baltimore, MD, United States, 3Blast Induced Neurotrauma Branch, Walter Reed Army Institute of Research, Silver Spring, MD, United States, 4Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States, 5Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, United States, 6Shock, Trauma, and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, United States
Synopsis
Compared to rodents, the ferret model has greater similarities to humans in terms of developmental process, brain structure and sophisticated behavior. In this study, we assessed the longitudinal changes in brain metabolism and impulsivity behavior in a ferret model that closely mimics the blast exposure conditions encountered by Warfighters. Ferrets demonstrated concomitantly increased behavioral impulsivity and metabolite alterations in prefrontal cortex following blast exposure. Our findings agree with clinical observations in patients, suggesting that this model is a good gyrencephalic animal model to study brain biochemical profile changes and neuropsychiatric alterations associated with blast exposure.
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