Abstract #3273

Early sex dependent changes in the default mode network of the TgF344-AD rat model of Alzheimer’s disease

Raúl Tudela¹, Emma Muñoz-Moreno², Xavier López-Gil², Federico Varriano³, and Guadalupe Soria^1,3

¹Biomedical Imaging Group, Consorcio Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Barcelona, Spain, ²Experimental 7T MRI Unit, Magnetic Resonance Imaging Core Facility, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain, ³Laboratory of Surgical Neuroanatomy, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain

Synopsis

TgF344-AD rat model has been revealed as an interesting animal model for investigating Alzheimer's disease. About two thirds of persons diagnosed with AD dementia are women, suggesting important sex and gender differences in risk factors for the development of AD. Therefore, it is of high interest to also investigate this issue in the AD animal models. In this study we present preliminary results regarding the effect of sex difference in the functional default mode network between young TgF344-AD rats and Wild-type.

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