Abstract #3274

VEGF overexpression in breast cancer xenograft significantly increases nanoparticle-mediated siRNA delivery and target gene downregulation

Shanshan Tan¹, Zhihang Chen¹, Yelena Mironchik¹, Noriko Mori¹, Marie-France Penet¹, Balaji Krishnamachary¹, and Zaver M. Bhujwalla^1,2,3

¹The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States, ³Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Effective tumor delivery is a major challenge in achieving small interfering RNA (siRNA) mediated gene silencing. Poor tumor vascularization can limit the delivery of therapeutic siRNA. Here, we used a VEGF overexpression breast cancer murine model and its wildtype counterpart to investigate the influence of increasing tumor vasculature on choline kinase-alpha siRNA nanoparticle delivery.

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