VEGF overexpression in breast cancer xenograft significantly increases nanoparticle-mediated siRNA delivery and target gene downregulation
Shanshan Tan1, Zhihang Chen1, Yelena Mironchik1, Noriko Mori1, Marie-France Penet1, Balaji Krishnamachary1, and Zaver M. Bhujwalla1,2,3
1The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States, 3Department of Radiation Oncology and Molecular Radiation Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States
Effective tumor delivery is a major challenge in achieving small interfering RNA (siRNA) mediated gene silencing. Poor tumor vascularization can limit the delivery of therapeutic siRNA. Here, we used a VEGF overexpression breast cancer murine model and its wildtype counterpart to investigate the influence of increasing tumor vasculature on choline kinase-alpha siRNA nanoparticle delivery.
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