Abstract #3276

Phase-Based T2 Mapping for Assessment of Liver Fibrosis in a Porcine Model

Ruvini Navaratna^1,2, Daiki Tamada², Sarvesh Periyasamy^2,3, Jennifer J Meudt⁴, Paul Laeseke^2,3, Dhanansayan Shanmuganayagam^4,5,6, Scott B Reeder^1,2,3,7,8, and Ali Pirasteh^1,2

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, United States, ⁵Surgery, University of Wisconsin-Madison, Madison, WI, United States, ⁶Center for Biomedical Swine Research and Innovation, University of Wisconsin-Madison, Madison, WI, United States, ⁷Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁸Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Fibrosis is the sequela of and the most important outcome predictor in chronic liver disease. MRI T2 mapping can provide safe and noninvasive detection/staging of liver fibrosis. However, current T2 mapping techniques suffer from prolonged acquisition times, prohibiting widespread clinical utilization. To address this unmet need, we evaluated the feasibility of a whole-liver, single-breath-hold, phase-based T2 mapping technique to assess liver fibrosis in a human-sized porcine model of liver fibrosis. We demonstrated a strong correlation between our phase-based liver T2 values and liver uptake of the fibroblast activation protein inhibitor on PET as well as the reference spin-echo T2 estimates.

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