Abstract #3276
Phase-Based T2 Mapping for Assessment of Liver Fibrosis in a Porcine Model
Ruvini Navaratna1,2, Daiki Tamada2, Sarvesh Periyasamy2,3, Jennifer J Meudt4, Paul Laeseke2,3, Dhanansayan Shanmuganayagam4,5,6, Scott B Reeder1,2,3,7,8, and Ali Pirasteh1,2
1Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2Radiology, University of Wisconsin-Madison, Madison, WI, United States, 3Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, 4Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI, United States, 5Surgery, University of Wisconsin-Madison, Madison, WI, United States, 6Center for Biomedical Swine Research and Innovation, University of Wisconsin-Madison, Madison, WI, United States, 7Medicine, University of Wisconsin-Madison, Madison, WI, United States, 8Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States
Synopsis
Fibrosis is the sequela of and the most important outcome predictor in chronic liver disease. MRI T2 mapping can provide safe and noninvasive detection/staging of liver fibrosis. However, current T2 mapping techniques suffer from prolonged acquisition times, prohibiting widespread clinical utilization. To address this unmet need, we evaluated the feasibility of a whole-liver, single-breath-hold, phase-based T2 mapping technique to assess liver fibrosis in a human-sized porcine model of liver fibrosis. We demonstrated a strong correlation between our phase-based liver T2 values and liver uptake of the fibroblast activation protein inhibitor on PET as well as the reference spin-echo T2 estimates.
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