Abstract #3278

Using amide proton transfer-weighted (APTw) MRI to detect severity and predict outcome after traumatic brain injury (TBI) in rats

Yinfeng Dong¹, Yanting Gu¹, Jianhua Lu², Jieru Wan¹, Shanshan Jiang², Raymond C. Koehler¹, and Jinyuan Zhou²

¹Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Synopsis

After TBI, secondary injury severity is difficult to determine. The objective of this study was to investigate the capacity of noninvasive APTw MRI to assess TBI injury in different brain regions and predict long-term neurobehavior outcomes. Fifty-five male and female rats were subjected to a controlled cortical impact with one of three different impactor depths to produce different degrees of TBI, and scanned on a 4.7 T horizontal bore animal imager. Our results suggest that APTw imaging can be used for detecting the level of inflammation and as a potential predictor of long-term outcomes from TBI.

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