Allelic difference in Apolipoprotein-E (APOE) is a well-known risk factor for the late-onset Alzheimer’s disease (AD) but how APOE affects brain functions and the subsequent cognitive declination remains unclear. Diffusion MRI followed by network topology analysis found that APOE deficiency in knockout mice resulted in altered neuronal network in the brain regions known to be affected by Alzheimer’s Disease. This study suggests the possible role of APOE in neuronal network organization, which might predispose brains to differential AD vulnerability.
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