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Abstract #3279

Apolipoprotein-E (APOE) Deficiency Leads to Neuronal Network Remodeling Characterized by Diffusion MRI and Graph Theory

Margaret Caroline Stapleton1, Philipp Boehm-Sturm2, Stefan Koch2, Susanne Mueller2, Devin Raine Everaldo Cortes1, and Yijen Wu1
1Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, 2Department of Experimental Neurology, Charite University Medicine Berlin, Berlin, Germany


Allelic difference in Apolipoprotein-E (APOE) is a well-known risk factor for the late-onset Alzheimer’s disease (AD) but how APOE affects brain functions and the subsequent cognitive declination remains unclear. Diffusion MRI followed by network topology analysis found that APOE deficiency in knockout mice resulted in altered neuronal network in the brain regions known to be affected by Alzheimer’s Disease. This study suggests the possible role of APOE in neuronal network organization, which might predispose brains to differential AD vulnerability.

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