Hyperpolarized 15N-BBCP as a novel probe of H2O2
Hyejin Park1, Jun Chen2, Ivan Dimitrov2,3, Jae Mo Park2,4, and Qiu Wang1
1Chemistry, Duke University, Durham, NC, United States, 2Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Philips Healthcare, Dallas, TX, United States, 4Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States
In this work, we have developed a novel de novo 15N-molecular probe, 15N-boronobenzyl-4-cyanopyridinium (15N-BBCP), for in vivo detection of H2O2. The long spin-lattice relaxation time (T1), high H2O2 sensitivity and selectivity, low cytotoxicity, and large chemical shift changes upon reaction suggest that the probe is suited for in vivo hyperpolarized 15N MRI.
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