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Abstract #3290

Multi-slab 3D ECLIPSE for whole brain lipid suppressed MRSI

Chathura Kumaragamage1, Peter B Brown1, Scott McIntyre1, Terence W Nixon1, Henk M De Feyter1, and Robin A de Graaf1
1Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States


The utility of ECLIPSE, a pulsed second order gradient insert allowing elliptical localization, was previously shown to provide high axial coverage for single slab MRSI acquisitions with robust lipid suppression. In this work we extend the ECLIPSE method with multi-slab localization that provides improved coverage, for applications in 3D MRSI acquisitions. A two-slab ECLIPSE-OVS method providing > 100-fold in mean lipid suppression was developed, with improved superior-inferior coverage. Simulation results show that a four-slab ECLIPSE method, based on OVS and IVS, can provide high-quality lipid suppression with whole-brain coverage.

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