Electrical tissue conductivity is an emerging quantitative diagnostic parameter, particularly for oncology. Conductivity typically increases with tumor malignancy, however, high conductivity per se is no indication for abnormal tissue, since many tissue types are highly conductive without being abnormal. An empirical rule correlates tissue conductivity with tissue water content. One possibility to analyze abnormality of tissue is thus to compare conductivity as measured with conductivity as expected from water content. The obtained difference yielding “normalized” conductivity might serve as a more direct measure of tissue abnormality. This study presents this concept using pathologic and healthy in vivo example cases.