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Abstract #3301

Mr CSDMotion-robust Constrained Spherical Deconvolution for multi-shell multi-tissue brain modelling of infants and other restless patients

Viljami Sairanen1
1BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, Children’s Hospital, Helsinki University Hospital and University of Helsinki, University of Helsinki, Helsinki, Finland


Investigation of brain structure of infants or other uncooperative patients using diffusion-weighted MRI is challenging due to subject motion artefacts. This work proposes a novel robust augmentation to current state-of-the-art multi-shell multi-tissue (MSMT) constrained spherical deconvolution (CSD) pipeline that accounts for these artefacts in both response function estimation and in deconvolution. A proof-of-concept is shown using multi-shell infant dataset and it is compared against the normal MSMT-CSD. The results indicate that motion artefacts can result in incorrect tissue type segmentations and fiber orientation distribution (FOD) estimates which could affect negatively any following analysis such as tractography or microstructural brain modelling.

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