Iron and Myelin Content in Multiple Sclerosis Lesions using Magnetic Susceptibility Source Separation
Reza Rahmanzadeh1,2, Po-Jui Lu1,2, Hyeong-Geol Shin 3, Matthias Weigel1,2, Thanh D. Nguyen4, Yi Wang4, Francesco La Rosa 5,6, Meritxell Bach Cuadra 5,6, Ernst-Wilhelm Radue1, Jens Kuhle2, Ludwig Kappos2, Jongho Lee 3, and Cristina Granziera1,2
1Translational Imaging in Neurology Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 2Neurologic Clinic and Policlinic, Switzerland, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 3Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 4Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 5Signal Processing Laboratory (LTS5), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 6Radiology Department, Center for Biomedical Imaging (CIBM), Lausanne University and University Hospital, Lausanne, Switzerland
Most multiple sclerosis (MS) white matter lesions (WMLs) appears hyperintense in quantitative susceptibility mapping (QSM). In the present study, we investigated the comparative contribution of myelin loss and iron deposit to QSM hyperintensity using a susceptibility source separation algorithm disentangling QSM- positive and QSM-negative susceptibility sources. Our results show that in most MS WMLs, demyelination is the source of QSM hyperintensity.
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