Abstract #3339

BOLD response in squirrel monkey brains evoked by green light without exogenous opsin

zhangyan yang^1,2, Pai-Feng Yang^2,3, Huiwen Luo^1,2, Feng Wang^2,3, Jamie L Reed^2,3, William A. Grissom^1,2,3, Li Min Chen^2,3, and John C. Gore^1,2,3,4,5

¹Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, ⁵Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States

Synopsis

Optogenetic stimulation combined with MRI detection of blood oxygenation level dependent (BOLD) effects has been developed as a powerful tool to delineate brain circuits. Opsin targeting specific cell types induce neural activity when irradiated with light at a specific wavelength. We detected robust BOLD effects in secondary somatosensory cortex (S2) and downstream interconnected caudate putamen (CPu) of monkey brains from irradiation with low-intensity green light without exogenous green light specific opsin, suggesting hemodynamic changes can be stimulated without any associated neural activity.

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