BOLD response in squirrel monkey brains evoked by green light without exogenous opsin
zhangyan yang1,2, Pai-Feng Yang2,3, Huiwen Luo1,2, Feng Wang2,3, Jamie L Reed2,3, William A. Grissom1,2,3, Li Min Chen2,3, and John C. Gore1,2,3,4,5
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, 5Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, United States
Optogenetic stimulation combined with MRI detection of blood oxygenation level dependent (BOLD) effects has been developed as a powerful tool to delineate brain circuits. Opsin targeting specific cell types induce neural activity when irradiated with light at a specific wavelength. We detected robust BOLD effects in secondary somatosensory cortex (S2) and downstream interconnected caudate putamen (CPu) of monkey brains from irradiation with low-intensity green light without exogenous green light specific opsin, suggesting hemodynamic changes can be stimulated without any associated neural activity.
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