A global spatially-adaptive method for task fMRI activation analysis with the advantage of alleviated spatial blurring
Zhengshi Yang1,2, Xiaowei Zhuang1,2, Mark Lowe3, and Dietmar Cordes1,2,4
1Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States, 2University of Nevada Las Vegas, Las Vegas, NV, United States, 3Cleveland Clinic, Cleveland, OH, United States, 4University of Colorado, Boulder, CO, United States
Accurately localizing brain activation is of great importance for promoting basic science and clinical application of task fMRI data. In this study, we proposed a global and time-efficient way to conduct brain activation analysis, with the property of spatially-adaptive smoothing and determining individual voxel’s activation status with wholebrain fMRI data considered simultaneously. We have demonstrated its advantage over traditional methods in alleviating spatial blurring artifacts.
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