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Abstract #3347

Structural abnormalities in olfactory brain regions in early Parkinson’s disease (PD) patients measured by high resolution MRI at 7T

Adrian Grant Paez1,2, Suraj Rajan3,4, Alex Y Pantelyat3, Liana I Rosenthal3, Andreia Faria5, Xinyuan Miao2,6, Ted M Dawson3, Peter C. M. van Zijl1,2, Vidyulata Kamath4, and Jun Hua1,2
1Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5Radiology and Radiological Science, Kennedy Krieger Institute, Baltimore, MD, United States, 6Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

We demonstrate significant structural abnormalities in the OB, primary and secondary olfactory brain regions in early PD patients measured by high resolution MRI at 7T. The MRI measures showed significant correlations with behavioral olfactory deficits in the participants.

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