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Abstract #3348

Metabolic Abnormalities in Bipolar Disorder Observed in the Putamen and Cerebellar Vermis with 7T MRS

Vincent Magnotta1, Jia Xu1, Jess Fiedorowicz2, Aislinn Williams3, Joseph Shaffer4, Gary Christensen5, Jeffrey Long6, Eric Taylor7, Leela Sathyaputri1, Jenny Gringer Richards1, Gail Harmata3, and John Wemmie3
1Radiology, University of Iowa, Iowa City, IA, United States, 2Psychiatry, University of Iowa, Ottawa, ON, Canada, 3Psychiatry, University of Iowa, Iowa City, IA, United States, 4Biosciences, Kansas City University, Kansas City, MO, United States, 5Electrical and Computer Engineering, University of Iowa, Iowa City, IA, United States, 6Paychiatry, University of Iowa, Iowa City, IA, United States, 7University of Iowa, Iowa City, IA, United States

Synopsis

This study used 31P and 1H MRS to study brain metabolic differences in bipolar disorder. Data from 64 participants with BD and 42 controls was acquired from the right putamen and cerebellar vermis were acquired at 7T. The study observed reduced pHi in support of prior work that has proposed mitochondrial dysfunction in BD where there is an impaired ability to utilize pyruvate in oxidative phosphorylation. A shift from oxidative phosphorylation toward glycolytic energy production likely increases lactate acid, CO2 levels, and free protons resulting in tissue acidosis. This shift in energy production may also lead to increased glutathione.

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