Abstract #3349

Brain functional connectivity in schizophrenia: disrupted network dynamics revealed by fMRI

Miguel Farinha¹, Conceição Amado², and Joana Cabral^3,4,5

¹Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal, ²Department of Mathematics and CEMAT, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal, ³Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal, ⁴Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford, Oxford, United Kingdom, ⁵Center for Music in the Brain, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark

Synopsis

We investigate differences between the dynamic exploration of resting-state functional connectivity (FC) states using fMRI data from 71 schizophrenia (SZ) patients and 74 healthy controls (HCs) by employing the Leading Eigenvector Dynamics Analysis (LEiDA) method to provide potential biomarkers of this disorder. We found a reduced ability of SZ patients to access and remain in a state of global BOLD phase coherence. Functionally meaningful states presented increased occurrence, limiting probability and altered dynamic transitions in SZ patients. These findings expose pronounced differences between SZ patients and HCs - supporting and developing current knowledge regarding disrupted brain dynamics in schizophrenia.

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