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Abstract #3350

Voxel-wise Comparison of Clinical 2D pCASL and DSC Perfusion of Intra-axial Brain Tumors

Johannes Devos1, Ronald Peeters1, and Philippe Demaerel2
1Radiology, UZ Leuven, Leuven, Belgium, 2Neuroradiology, UZ Leuven, Leuven, Belgium


Dynamical susceptibility contrast (DSC) and arterial spin labeling (ASL) are MRI techniques to quantify brain tissue perfusion. A voxel-wise analysis in 23 patients showed a moderate to strong linear relationship between tumoral cerebral blood flow measured by 2D echo planar imaging, pseudo-continuous ASL (pCASL) and leakage corrected, cerebral blood volume measurements by DSC. Additionally, mean and 90th percentile of tumor perfusion of all patients showed a strong linear relationship. In conclusion, 2D EPI pCASL is a viable alternative to DSC for perfusion measurements of brain tumors.

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