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Abstract #3351

Role of PET and ASL simultaneously acquired imaging biomarkers in differentiating progression from radionecrosis in glial brain tumors

Nadya Pyatigorskaya1, Arnaud Pellerin2, Maya Kalife3, Laura Rozenblum-Beddok4, Marc Bertaux2, Marine Soret2, Lydia Yahia-cherif3, and Aurélie Kas2
1CENIR, ICM, Paris, France, 2Pitié-Salpêtrière Hospital, APHP, Sorbonne universite, Paris, France, 3ICM, Paris, France, 4Pitié Salpêtrière, APHP, Paris, France


We aimed at investigating the methods based on coupling of of amino-acid metabolism (18F-DOPA-PET) measurements and cerebral blood flow (CBF) maps to evaluate the diagnostic performance of PET/MRI in glioma imaging. Tumor isocontour maps and T-maps were created using SPM and metabolic/perfusion abnormalities were evaluated with the asymmetry index z-score. SPM map analysis of significant-size clusters and semi-quantitative evaluation were performed and compared to gold standard diagnosis. Both the tumor isocontour maps and T-maps showed the highest specificity for ASL and sensitivity for 18F-DOPA analysis, allowing high diagnostic performance in differentiating between progression and radionecrosis particularly in high-grade treated gliomas.

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