Conventional MRI such as T2 and FLAIR do not show sub-regional intensity changes in peritumoral infiltration zone of glioblastoma and cannot visualize tumor margins. Here, we implemented a new method for sub-volumetric analysis of glioblastoma and investigated T1 and T2 relaxation properties in the peritumoral infiltration zone. The results show a decrease in T1 and T2 relaxation times as a function of distance from the contrast-enhanced T1 solid tumor region to the periphery. Our method may help to better select regions for biopsy, to determine the surgical resection margin and improve radiation therapy planning and post-therapeutic progress controls.
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