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Abstract #3352

Quantitative magnetic resonance imaging combined with three-dimensional image analysis in glioblastoma

Gergely Bertalan1, Julia Onken2, Simone Schwedler3, Bernd Hamm1, Georg Bohner3, and Edzard Wiener3
1Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Neurosurgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Neuroradiology, Charité - Universitätsmedizin Berlin, Berlin, Germany


Conventional MRI such as T2 and FLAIR do not show sub-regional intensity changes in peritumoral infiltration zone of glioblastoma and cannot visualize tumor margins. Here, we implemented a new method for sub-volumetric analysis of glioblastoma and investigated T1 and T2 relaxation properties in the peritumoral infiltration zone. The results show a decrease in T1 and T2 relaxation times as a function of distance from the contrast-enhanced T1 solid tumor region to the periphery. Our method may help to better select regions for biopsy, to determine the surgical resection margin and improve radiation therapy planning and post-therapeutic progress controls.

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